Since 2016, the department has operated a specialized educational and scientific laboratory of molecular pharmacology, chemogenomics, and biogerontology (MPCB Lab), which involves the best students. The laboratory is equipped with the most modern analytical and technological equipment.
Research team of the Educational and Research MPCB Laboratory is growing dynamically in terms of quantity and quality and is currently as follows:
Doctor of Technical Sciences, Professor, head of the scientific direction "Fundamental technologies of active longevity" Volodymyr Bessarabov;
Doctor of Technical Sciences, Associate Professor, Leading Researcher Olena Ishchenko;
Candidate of Chemical Sciences, Associate Professor, Senior Research Fellow Galyna Kuzmina;
Candidate of Biological Sciences, Associate Professor, Senior Research Fellow Hanna Kharytonenko
Assistant, PhD, Senior Research Fellow Vadym Lisovyi;
Research Associate, Postgraduate Student Viktoriia Lyzhniuk;
Senior Research Fellow, Candidate of Technical Sciences, Associate Professor Roman Kachan;
postgraduate student Olha Kovalevska;
postgraduate student Vladyslav Udovytskyi;
postgraduate student Volodymyr Yaremenko;
postgraduate student Volodymyr Fedorenko;
postgraduate student Ramil Vakhitov;
postgraduate student Yevhenii Subota;
postgraduate student Mikael Yehanian;
postgraduate student Svitlana Sterenchuk;
postgraduate student Andrii Mykhalets;
postgraduate student Sun Zeyuan;
research associate Anastasiia Behdai;
senior laboratory assistant Vladyslav Zaiets;
senior laboratory assistant Olha Syviuk;
laboratory assistant Ihor Danylenko;
laboratory assistant Mariia Rozumnenko.
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Educational and scientific laboratory of Molecular Parmacology, Chemogenomics and Biogerontology |
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Address: Kyiv, 2 Mala Shyianovska Street,
Building 1, Laboratories 1-0223, 1-0238, 1-0240, 1-0127
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Structural divisions of the Educational and scientific laboratory MPCB:
Division A. Development and preclinical research of APIs and medicinal products.
- A1. Cognitive motivation, research quality management, and information storage sector.
- A2. Solid dosage form design sector.
- A3. API design sector.
- A4. HPLC, UV and FTIR spectral analysis, biochemical and kinetic research sector.Підрозділ Б. Технологічної розробки та біофармацевтичних досліджень лікарських засобів.
Division B. Pharmaceutical Materials Science and Nanotechnology
The opening of the sector of pharmaceutical materials science and nanotechnology at the Research Laboratory of Molecular Pharmacology, Chemogenomics, and Bioherontology took place in 2025 during the conference "KyivLvivPharma-2025. Pharmaceutical Technology and Pharmacology in Ensuring Active Longevity," which was dedicated to the 95th anniversary of the founding of KNUTD. The main areas of work in this department include the creation of highly soluble polymer composite systems to increase the solubility and bioavailability of active pharmaceutical ingredients, as well as the development of materials based on carbon quantum dots and nanofibers for pharmaceutical and cosmetic applications. The renovation and equipping of the laboratory was carried out with the assistance of JSC “Farmak”.

DIRECTION OF SCIENTIFIC ACTIVITY
Fundamental technologies for active longevity.
MAIN TOPICS OF PROSPECTIVE SCIENTIFIC RESEARCH:
- Development of composite materials based on pharmaceutically acceptable polymers to increase the bioavailability of active pharmaceutical ingredients.
- Study of the biological activity of extracts from biotechnological plant raw materials with the aim of developing pharmaceutical compositions with anti-inflammatory and antiviral effects.
- In silico and in vitro research of the pleiotropic effects of biologically active substances as antioxidants, inhibitors of human cholinesterases and 15-lipoxygenase, aimed at finding new active pharmaceutical ingredients for drugs to treat neurodegenerative diseases.
- Development of drugs with controlled release of active pharmaceutical ingredients.
- Development of perfumes and cosmetics with therapeutic properties.
- Development and research of nanostructured environmentally safe systems for decontamination of organophosphorus toxic substances (pesticides and active pharmaceutical ingredients) and technologies for cleaning equipment at chemical and pharmaceutical enterprises.
LABORATORY EQUIPMENT
- Labsphere UV-1000 ultraviolet SPF analyzer (Labsphere, USA).
- Suntest CPS device for simulating solar radiation and conducting accelerated tests for light resistance and photostability of materials (Atlas, USA) with a xenon lamp.
- Optizen POP scanning UV-Vis spectrophotometer (Mecasys, South Korea).
- Specord 200 scanning UV-Vis spectrophotometer (Analytik Jena, Germany).
- Specord 200 Plus scanning UV-Vis spectrophotometer (Analytik Jena, Germany).
- Multifunctional tablet analyzer Varioskan Flash (Thermo Scientific, USA) (measurement of fluorescence intensity (FI), time-resolved fluorescence (TRF), optical density, and end-point luminescence).
- Multiskan Sky microplate UV-Vis spectrophotometer (Thermo Scientific, USA) with an attachment for studying microquantities of liquids.
- Nicolet AVATAR 360 FTIR spectrometer (Thermo Scientific, USA).
- Perkin Elmer Spectrum 1000 FTIR spectrophotometer (Perkin Elmer, USA).
- Biochem SA semi-automatic biochemical analyzer (High Technology, USA).
- Agilent 1100 Series HPLC chromatograph (Agilent, UK).
- Amperometric Detector (Biotech Instruments, UK).
- RO-4 laboratory water treatment unit (Werner, Germany).
- Sartorius Stedim biotech Arium H2O pro DI-T high-purity water production unit (Sartorius, UK)
- AccuLab ALC 110.4 analytical balance (Sartorius, UK).
- pH-150 MI pH meter.
- Buchi Melting Point B-545 melting point determination device (Buchi, Switzerland).
- Programmable Rheometer Brookfield Model DV-III (Brookfield, UK).
- Termo Temperature Controlled Bath PSl Rheotek TCB-8 (Brookfield, UK).
- Buchi Extraction Unit B-815 (Buchi, Switzerland).
- Brookfield TC-200, TC-350 thermostat (Brookfield, UK).
- Vankel VK7000, VR750D, VK8000 apparatus for studying the dissolution kinetics of solid dosage forms (Vankel, USA).
- PharmaTest (Germany) apparatus for studying the kinetics of disintegration of solid dosage forms.
- SM-8 laboratory microcentrifuge (Micromed, China).
- SM-3 laboratory centrifuge (Micromed, China).
- PHOTOCHEM robotic analyzer of antioxidants and free radicals (Analytik Jena, Germany).
- SF1 shaker (Stuart, UK).
- VK 200 tablet hardness tester (Varian, Inc., USA).
- KP-150 MI portable conductometer (Russia).
- Unicam 929A Spectrometer atomic absorption spectrometer (Unicam, USA).
- DB-10C cuvette thermostat (Biosan, Latvia).
- TS-100C Thermoshaker with cooling for Eppendorf tubes with SC-24C unit (Biosan, Latvia).
- VanKel VK200 tablet hardness tester (Vankel, USA).
- Sanyo Gallenkamp melting point apparatus (Sanyo, Japan).
- RADWAG MA 50.R moisture analyzer (RADWAG, Poland).
- KFK-2 photocolorimeter (Russian Federation).
- Lambda 25 scanning UV-Vis spectrophotometer (Perkin Elmer, USA).
- AD8000 laboratory multimeter pH/mV/EC/TDS/Temp (Adwa, Hungary).
- EP-1 Vers2 tablet press (Erweka, Germany).
- DT 800 LH dissolution tester (Erweka, Germany).
- ZT 323 solid dosage form disintegration tester (Erweka, Germany).
- DTG 200i solid dosage form disintegration tester (Copley Scientific, UK).
- TAR 200 tablet abrasion tester (Erweka, Germany).
- TBH525WTD multifunctional tablet tester (Erweka, Germany).
- FRL 804 sampling device (Erweka, Germany).
- BMG Labtech NEPHELOstar Microplate Reader Nephelometer.
- TDS centrifugal polymer fiber forming device (China).
- Mini Spray Dryer B-290 (BUCHI, Switzerland).

PAID SERVICES
- Development and validation of bioanalytical methods for determining the concentration of active pharmaceutical ingredients (APIs) and their metabolites in various biological fluids and tissues (blood plasma, urine, etc.);
- Routine analysis of samples according to validated methods;
- Determination of pharmacokinetic parameters;
- Preparation of reports on research results in accordance with national and international requirements.
A set of in vitro studies in the ADMET category (absorption, distribution, metabolism, excretion, and toxicity) used in the modern global pharmaceutical industry to develop and improve new drug candidates at an early preclinical stage.
A wide range of in silico studies in the field of chemoinformatics, chemogenomics, and bioinformatics:
- Selection of various compounds based on structural or pharmacophore criteria from the composition of APIs registered in global pharmacopoeias in accordance with the requirements of the task (customer).
- Selection of candidate molecules using virtual screening based on molecular docking and pharmacophore modeling.
- Evaluation of physicochemical properties based on computer calculations or experiments.
- Molecular dynamics calculations and analysis of biomolecule conformations.
- Determination of binding sites and construction of a pharmacophore model.
- Computational assessment of specific pharmacological activity.
- Potential pharmacological profile using ADME-Tox tests.
- Establishment of structure-activity (QSAR) and structure-property (QSPR) relationships.
- In silico prediction of AFI metabolism sites for cytochromes P450 (5 major human ones).
- In silico prediction of API-induced changes in gene expression profiles (separately for protein and mRNA).
- In silico prediction of API cytotoxicity for tumor and non-tumor cell lines.
- In silico prediction of LD50 endotoxicity (acute toxicity) based on the results of QSAR analysis of the toxicological effects of chemicals on model organisms (rats) for four types of administration (oral, intravenous, intraperitoneal, subcutaneous).
- In silico prediction of exotoxicity (ecological toxicity) based on QSAR calculation for the following indicators: 96-hour minnow (Latin: Phoxinus) at 50% lethal concentration, 48-hour Daphnia magna (Latin: Daphniamagna) at 50% lethal concentration, Tetrahymena pyriformis at 50% growth inhibition concentration and bioaccumulation factor.
POSSIBILITIES OF PRE-CLINICAL API RESEARCH
- Physico-chemical properties.
- Determination of melting point (installation for determining the melting point of Buchi Melting Point B-545 (Buchi, Switzerland).
- Determination of dissolution in water, polar and non-polar solvents (kinetic and thermodynamic measurements with UV-Vis and HPLC quantitative detection of solutes).
- Analysis of chemical stability in aqueous buffer solutions at different pH values (kinetic and thermodynamic measurements with UV-Vis and HPLC quantitative detection of solutes).
- LogD / LogP lipophilicity study.
- Investigation of the dynamic viscosity and other rheological characteristics of liquid and pasty APIs (Programmable Rheometer Brookfield Model DV-III (Brookfield, UK)).
Metabolism of API in vitro
- Kinetic studies of the stability of API in human serum (with UV-Vis and HPLC quantitative detection of substances).
Specific pharmacological activity:
- Kinetic studies of inhibition of human serum butyrylcholinesterase with determination of Ki and IC50 (with UV-Vis quantitative detection).
- Kinetic studies of acetylcholinesterase inhibition with determination of Ki and IC50 (with UV-Vis quantitative detection).
- Kinetic studies of 15-lipoxygenase inhibition with determination of Ki and IC50 (with UV-Vis quantitative detection).
- Kinetic studies of activation / inhibition of superoxide dismutase (SOD) with determination of Ki and IC50 (with UV-Vis quantitative detection).
- Study of inhibition of peroxidation of human plasma proteins (with UV-Vis quantitative detection).
- Study of inhibition of lipid peroxidation of human blood plasma (with UV-Vis quantitative detection).
- Investigation of inhibition of free radical formation in the chemical RedOx system based on auto-oxidation of adrenaline (with UV-Vis quantitative detection).
- In vitro study of the potential cardiotonic activity of API (with UV-Vis quantitative detection).
Investigation of the photoprotective properties of API in different ranges of the UV spectrum (with UV-Vis quantitative detection).


LABORATORY TECHNOLOGICAL AND BIOPHARMACEUTICAL RESEARCH CAPABILITIES FOR MEDICINAL PRODUCTS
- Pharmacopoeial dissolution test for solid dosage forms (Vankel VK7000, VR750D, VK8000 dissolution kinetics testing equipment (Vankel, USA), followed by UV-Vis or HPLC quantitative detection).
- Conducting comparative in vitro studies to confirm the equivalence of medicinal products in solid dosage forms for systemic use (Vankel VK7000, VR750D, VK8000 (Vankel, USA) dissolution kinetics testing equipment, followed by UV-Vis or HPLC quantitative detection).
- Pharmacopoeial “Disintegration” test for solid dosage forms (disintegration kinetics testing equipment (PharmaTest, Germany), followed by UV-Vis or HPLC quantitative detection).
- Determination of the weight, hardness, diameter, and thickness of tablets.
- Study of dynamic viscosity and other rheological characteristics of ointments, pastes, and gels (Programmable Rheometer Brookfield Model DV-III (Brookfield, UK)).
- Study of chemical compatibility and stability of APIs and excipients.
POSSIBILITIES OF TECHNOLOGICAL RESEARCH IN THE PRODUCTION OF MEDICINES
- Development of technology (chemical production schemes, technological schemes, and technological production regulations) for APIs and medicines in accordance with GMP requirements.
- Development of regulatory documentation at various levels for the production of APIs and medicinal products.
Identification of risks to quality in the technological process of API and medicinal product manufacturing.
PHOTO LABORATORY




Participation in scientific and practical conferences, scientific research, and publication of scientific literature
Since 2015, the Department of Industrial Pharmacy at KNUTD has been organizing the International Scientific and Practical Conference “KyivPharma. Pharmacology and Pharmaceutical Technology in Ensuring Active Longevity.” (https://knutd.edu.ua/pod-ta-publkats/news/12904/ , https://knutd.edu.ua/pod-ta-publkats/news/14164/, https://knutd.edu.ua/pod-ta-publkats/news/16176/), which is held every two years.
Based on the results of the conference in 2023, a collection of scientific papers «CHEMICAL AND BIOPHARMACEUTICAL TECHNOLOGIES» was published by Nordic Sci Publisher, Tallinn.
On November 20-21, 2025, the staff of the Department of Industrial Pharmacy, together with scientific and pedagogical workers of the National University “Lviv Polytechnic”, scientists from the L. M. Litvinenko Institute of Physical Organic Chemistry and Coal Chemistry of the National Academy of Sciences of Ukraine, and specialists from JSC Farmak organized and held the VII International Scientific and Practical Conference "KyivLvivPharma-2025. Pharmaceutical Technology and Pharmacology in Ensuring Active Longevity," dedicated to the 95th anniversary of the founding of KNUTD. The event also included the 13th specialized scientific and practical conference with international participation of the School of Young Scientists of JSC Farmak, “Science, Innovation, and Quality in Modern Pharmaceutical Production,” dedicated to the 100th anniversary of the pharmaceutical company Farmak. The main partner and sponsor of the conference was the pharmaceutical company Farmak, with sponsors including Chemlaboreactive LLC, Alsi Ltd., and LEM Ukraine LLC. Information partners included the magazine Pharmaceutical Industry and the publication Weekly Pharmacy.
More than 300 participants from various countries took part in the conference, including Ukraine, Poland, Lithuania, Estonia, Croatia, Sweden, France, Switzerland, the USA, Great Britain, Germany, and Italy. More than 150 participants attended in person.


Postgraduate supervisors conduct scientific research within the framework of comprehensive research topics of the Department of Industrial Pharmacy. The results of this activity are regularly published in professional periodicals. Thus, KNUTD annually develops and implements a thematic plan for research and development, which determines the areas of scientific research carried out within the working day of the KNUTD Scientific and Production Complex. Bessarabov V., Strashnyi V., Goy A., Hureieva S., Ishchenko O., Kuzmina H., Nikitina O., Roik O., Tarasenko H. are the leaders of initiative scientific topics registered with UkrINTEI. Assistant Professor, PhD Vadym Lisovyi is the scientific supervisor of contract research projects and the lead researcher for R&D project No. 16.04. 79 MV DB on the topic “Development of technology for providing primary medical care to military personnel and civilians with mine-blast injuries and burns,” which is being carried out at the expense of the State Budget of Ukraine (01.01.2025 - 31.12.2026). The executors of this research project are young scientists from the Department of Industrial Pharmacy.
A collective monograph «Modern physical-organic chemistry and pharmacy» was published in the European Union with the participation of graduate students Nordic Sci Publisher (Tallinn, Estonia).
